Therapeutic benefits of roses

A meeting place for rose breeders.
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Bregingew
Posts: 3
Joined: Thu Oct 14, 2021 2:59 am

Therapeutic benefits of roses

Post: # 73438Post Bregingew
Mon Nov 01, 2021 12:43 pm

Hi yall, I'm new to the forum and am based in South carolina. I am really interested to do some breeding with medicinal applications in mind. So if you know of any good articles or information - even if it's anecdotal, I would appreciate it. I also wanted to share a review paper that I found that talks about rose hips in medicine, its a really interesting read:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485961

roseus
Posts: 13
Joined: Mon Nov 18, 2019 4:46 pm

Re: Therapeutic benefits of roses

Post: # 73452Post roseus
Fri Nov 05, 2021 2:11 pm

Hi and welcome! Rose breeding with medicinal applications seems to be a really interesting field. Perhaps these two articles could meet your interest:
https://www.questjournals.org/jraas/pap ... 010810.pdf; https://onlinelibrary.wiley.com/doi/ful ... /php.13126

Karl K
Posts: 1452
Joined: Sat Jun 02, 2012 4:49 pm

Re: Therapeutic benefits of roses

Post: # 73604Post Karl K
Tue Dec 28, 2021 11:17 pm

The Damask roses have a long history of use as a stool softener. Dried and powdered petals of the red roses, rich in tannins, have been use as an astringent and treatment for diarrhea. Petals of the yellow rose (Rosa foetida) have been used as a stomachic ... to tone the stomach and stimulating appetite. And now this:

https://www.sid.ir/en/journal/ViewPaper.aspx?id=488917
Journal of Herbal Drugs 5(4): 209-213 (2015)
Rosa foetida Herrm. flowers as a future natural antibacterial agent against the main cause of skin burn wound infections, Pseudomonas aeroginosa.
Rezghi Maedeh, Hosseini Doust Seyed Reza, Asgarpanah Jinous
Abstract
Background & Aim: Belongs to Rosaceae family, Rosa foetida is one the Persian native plants which has not been investigated biologically. As it is traditionally used topically as poultice to treat infectious skin burns, the present paper focused on the assessment of the antibacterial activities of different extracts of R. foetida flowers against the main cause of skin burn wounds infections, Pseudomonas aeruginosa.
Experimental: The antibacterial activity and MIC value determination were investigated by cup plate method and micro plate dilution method respectively.
Results: All R. foetida extracts had inhibition activity on the growth of P. aeruginosa of which the aqueous and methanol extracts exhibited the strongest activities. Inhibition zone diameter and MIC values of the concentration of 125 mg/ml of both extracts were found to be somehow the same as those of the standard drug, Imipenem/Cilastatin (8.8 mg/ml).
Recommended applications/industries: Results demonstrated that the plant is effective against the standard and pathogenic strains of P. aeruginosa and could be a potential source of effective natural antibacterial compounds to be applied in further phytochemical and in vivo biological studies.

https://ijmapr.areeo.ac.ir/article_121461.html?lang=en
Iranian Journal of Medicinal and Aromatic Plants 36(1): 171-182 (March and April 2020)
Antioxidant activity and total phenolic compounds of aqueous and ethanolic extracts of Iranian yellow rose (Rosa foetida Herrm.) and evaluation of their antimicrobial activity against Salmonella enterica, Bacillus cereus, and Staphylococcus aureus.
Z. Noroozi 1, M. Moslehisahd 2, M. H. Salehi Surmaghi 3
1 Nutrition and Food Sciences Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2 Department of Food Science and Technology, Safadasht Branch, Islamic Azad University, Tehran, Iran
3 Department of Pharmacognosy, Faculty of Pharmacy and Medicinal Plants Research Center, Tehran University of Medical Sciences, Tehran, Iran
Abstract
Rosa foetida Herrm. is one of the native Rosa species in Iran known as Iranian yellow rose. The main growth area of this plant in Iran is the western parts especially Kurdistan. It is used for kidney disorders treatment and as a source of vitamin C. The aim of this study was to evaluate the ability of free radical scavenging, determination of phenolic compounds, and antimicrobial activity of aqueous and ethanolic extracts of yellow rose flowers. The antioxidant activity and total phenolic compounds of extracts of yellow rose were determined using ABTS free radical scavenging assay and Folin-Ciocalteu method, respectively. Dilution method was used to determine the minimal inhibitory concentration (MIC) against Salmonella enterica, Bacillus cereus and Staphylococcus aureus. The results showed a significant positive correlation between free radical scavenging percentage and the concentration of the extracts (P<0.05). In the range of 0.39-12.50 mg ml-1 concentrations, the aqueous extract had more antioxidant activity than ethanolic extract (P<0.05). The 50% inhibitory concentration (IC50) of aqueous and ethanolic extracts was calculated to be 217.069 and 223.116 μmol, respectively. The results of total phenolic compounds test in extracts showed a positive and significant relationship between the concentration of the extracts and their phenolic compounds content, and the aqueous extract contained more phenolic compounds as compared with the ethanolic extract (P<0.05). The highest antimicrobial effect of aqueous and ethanolic extracts was observed against Staphylococcus aureus and Salmonella enterica, respectively (P<0.05). Due to the favorable antioxidant and antimicrobial properties of this plant, its use as a natural additive in the food industry is recommended.

Bregingew
Posts: 3
Joined: Thu Oct 14, 2021 2:59 am

Re: Therapeutic benefits of roses

Post: # 73605Post Bregingew
Wed Dec 29, 2021 12:43 am

Thanks! I'll have a look at all of these resources. I am currently rotating in a drug discovery lab and may turn this topic into my dissertation. Would love to look at the active compounds and determine the effectiveness of individual compounds on certain ailments. I feel like doing something with roses in my PhD program would be fun and drive me to be very successful. I'm hoping to be more active in the forum as I start my first breeding season this next year. This year I'm just collecting open pollinated hips and making sure I have a good method for germination etc. If something comes out of it, ill post pictures!

roseus
Posts: 13
Joined: Mon Nov 18, 2019 4:46 pm

Re: Therapeutic benefits of roses

Post: # 73606Post roseus
Wed Dec 29, 2021 10:53 am

https://pubmed.ncbi.nlm.nih.gov/31138475/

Rosa canina - Rose hip pharmacological ingredients and molecular mechanics counteracting osteoarthritis - A systematic review
Joerg Gruenwald 1 , Ralf Uebelhack 2 , Margret Irmgard Moré 3

Abstract
Background: The successful use of rose hip for the treatment of osteoarthritis is well documented. Several randomized placebo controlled double-blind studies, as mono or combination therapy, have demonstrated treatment efficacy as well as excellent tolerability.

Purpose: This review focuses on the molecular mechanism underlying the clinical effects of rose hip in osteoarthritis (OA).

Methods: The database Medline was screened - using the search term "Rosa canina" or "rose hip" - for publications on pharmacological or mechanistic studies with relevance to OA; in addition for findings on pharmacologically active constituents as well as clinical studies. The screening results were complemented by following-up on cited literature.

Results: In particular, 24 pharmacological studies on Rosa canina or preparations thereof were considered relevant. Potent antioxidant radical scavenging effects are well documented for numerous rose hip constituents besides Vitamin C. Furthermore, anti-inflammatory activities include the reduction of pro-inflammatory cytokines and chemokines, reduction of NF-kB signaling, inhibition of pro-inflammatory enzymes, including COX1/2, 5-LOX and iNOS, reduction of C-reactive protein levels, reduction of chemotaxis and chemoluminescence of PMNs, and an inhibition of pro-inflammatory metalloproteases.

Conclusion: The antioxidant and anti-inflammatory effects of Rosa canina match its clinical action - especially considering new findings on the pharmacological disease pattern of OA. The entirety of several compounds including phenolics, terpenoids, galactolipids, carotenoids, fruit acids and fatty oils can be considered responsible for the observed pharmacological and clinical effects. Further research is needed to eludicate how and in which manner single rose hip compounds interact with their molecular pharmacological targets.

Karl K
Posts: 1452
Joined: Sat Jun 02, 2012 4:49 pm

Re: Therapeutic benefits of roses

Post: # 73607Post Karl K
Wed Dec 29, 2021 10:09 pm

I have a particular interest in Rosa alba, because it seems to have been one of the four types the ancient Nabateans cultivated. It must have had more than aesthetic value to be cherished in a desert area. Modern uses are welcome, and traditional uses may help guide the way.

https://www.researchgate.net/publicatio ... _Rosa_Alba
Biotechnology & Biotechnological Equipment 24(sup1):512-515 (April 2014)
Antimicrobial Activity of Essential Oil from Rosa Alba
V. Gochev, A. Dobreva,T. Girova & A. Stoyanova
Antimicrobial activity of two trade lots of essential oils from Rosa alba L. against Gram-positive bacteria, belonging to genera Staphylococcus and Bacillus, Gram-negative bacteria, belonging to genera Escherichia, Pseudomonas, Salmonella and Citrobacter and yeasts, belonging to genera Candida was investigated. It was determined that Gram-positive bacteria were more sensitive and Gram-negative bacteria, especially Pseudomonas spp., were more resistible to essential oils and pure components. The major pure constituents citronellol, geraniol and nerol demonstrated higher antimicrobial activity in comparison with essential oil samples.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398089/
Plants (Basel). 2021 Aug; 10(8): 1721.
Metabolomic Profiles of Essential Oils from Selected Rosa Varieties and Their Antimicrobial Activities
Esraa A. Elhawary, Nada M. Mostafa, Rola M. Labib, and Abdel Nasser Singab
Traditionally, Rosa banksiae var. banksiae Ait. was used for its antifungal activity, while Rosa polyantha Thunb. leaves were used as a poultice applied to sores and for skincare. The ability of Rosa species to control microbes may be attributed to their high content of vitamin C, in hips and flowers, and other different phenolic and flavonoid constituents [2]. Indigenous people in North America traditionally used roses for cough treatment, especially in children as a decoction and inhalation therapy [3], while ancient Chinese utilized Rosa as a healing plant for sore throat and common cold due to its immune-stimulatory activity [4].

Karl K
Posts: 1452
Joined: Sat Jun 02, 2012 4:49 pm

Re: Therapeutic benefits of roses

Post: # 73608Post Karl K
Thu Dec 30, 2021 12:12 pm

Jane Buckle PhD, RN, in Clinical Aromatherapy (Third Edition), 2015
Insomnia
Rose
Most people enjoy the smell of roses. Rose is perhaps the most recognized and popular aroma in the world. Despite essential oil of rose being expensive, the cost may be justified where chronic insomnia is concerned. Both Macht and Ting (1921) and Rovesti and Columbo (1973) demonstrated that rose (Rosa damascena) essential oil has sedative effects. The sedative effects were replicated in a later study by Hongratanaworakit (2009). This study found that rose oil caused “significant decreases of breathing rate and systolic blood pressure that indicate a decrease of autonomic arousal.” Jahangir et al (2008) compared the effect of steam-distilled rose petals (Ruh gulaab), rose distillate, or diluted rose distillate when given orally (three times daily) to 36 people with insomnia. The distilled rose petals had the greatest effect on insomnia with 66.6% (eight people) claiming total relief from insomnia. An added bonus was that rose had a positive effect on constipation.

In my experience, as well as that of my students and patients, rose is a strong contender to use for anxiety and for insomnia. Rose is in my own personal sleep potion when I travel and it certainly works for me.
To be clear, the author wrote that it works for her. I haven't tried it.

Karl K
Posts: 1452
Joined: Sat Jun 02, 2012 4:49 pm

Re: Therapeutic benefits of roses

Post: # 73609Post Karl K
Thu Dec 30, 2021 2:57 pm

https://www.semanticscholar.org/paper/T ... 565c965303
Biochemical and biophysical research communications 229(1):73-9. (Dec 4, 1996)
The anti-HIV activity and mechanisms of action of pure compounds isolated from Rosa damascena
N. Mahmood, S. Piacente, C. Pizza, A. Burke, A. Khan, A. Hay
Abstract
Water and methanol extracts of Rosa damascena exhibited moderate anti-HIV activity. The anti-viral activities of 9 compounds isolated from the methanol extract were compared. The tetrahydroxyflavanone (kaempferol, 1), was effective in reducing the maturation of infectious progeny virus apparently due to selective inhibition of the viral protease. On the other hand the pentahydroxyflavone (quercetin, 2) and two 3-substituted derivatives of kaempferol appeared to inhibit HIV-infection by preventing binding of gp120 to CD4. 2-Phenylethanol-O-(6-O-galloyl)-beta-D-glucopyranoside 8 interacted irreversibly with gp120 and neutralized virus infectivity. The differences in the modes of action of 1 and 8 can account for the apparent synergy of their anti-viral activities.

roseus
Posts: 13
Joined: Mon Nov 18, 2019 4:46 pm

Re: Therapeutic benefits of roses

Post: # 73619Post roseus
Sat Jan 01, 2022 10:50 am

https://papers.ssrn.com/sol3/papers.cfm ... id=3612898

Rose and In-vitro Inhibition of SARS-CoV-2 spike: ACE-2 Interaction

Abstract

The study was performed to evaluate the novel potentials of red rose extract to inhibit SARS-CoV-2 spike protein-Ace2 receptor interaction in vitro. ACE2 receptors were His-labelled, and the interaction was studied by chemiluminescence after the addition of anti-His HRP and HRP substrate. The inhibition of SARS-CoV-2 and ACE2 was seen in a dose-dependent sequence. The 50% inhibitory concentration was observed at 0.75 percent v/v of the rose extract, and the 90% inhibition was seen at about 1.8 percent v/v. Steam inhalation or nebulization could be simple methods of delivering rose extract to the lower respiratory tract and pulmonary tissues. There is a potential for the rose extract to inhibit SARS-CoV-2 and ACE2 receptor inhibition in-vitro, which could have beneficial effects in Covid-19 treatment. Further tests need to be performed to study the therapeutic benefits in vivo.

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