Ames 5 was a wonderful species hybrid developed, a combination of cold hardiness and floriferousness. It was developed 84 years ago (1932) and unfortunately (if I recall correctly) no progress was made with it to develop newer types of shrub roses. Perhaps a cold hardier type of Hybrid Musk could have been developed, which certainly would have been very attractive in the landscape.
I have thought it might be productive to make this cross again but using a cold hardier Rosa blanda (woodsii). However, as one avenue to pursue to develop cold hardy (Zone 3) Climbers, I now lean to developing a Rosa maximowicziana x Rosa woodsii species hybrid. Rosa maximowicziana has a prostrate growth habit but is cold hardier (it's cold hardy to Zone 4 but can also survive quite nicely in Zone 3) than Rosa multiflora. But I wouldn't stop there. I think it's necessary to inject disease resistance, and the best potential for that is likely from Rosa wichurana. So a Rosa wichurana x R. woodsii hybrid would have to be developed to maintain relatively good cold hardiness and then combined with the Rosa maximowicziana x R. woodsii hybrid. Rosa wichurana, of course, also has a prostrate growth habit. Note: All three of these species are diploids.
A long term project for sure, but I think it's an interesting one to pursue, which I'm doing. I made a few Rosa wichurana x R. woodsii crosses last year.